| CRASH points |
| 0 | 1 | 2 |
| Ado-trastuzumab emtansine (TD-M1) | Bendamustine 90mg/m2 + rituximab | 5-FU/LV (Roswell-Park) |
| Capecitabine 2g/m2 | Capecitabine 2.5g/m2 +/- trastuzumab | 5-FU/LV (Mayo) |
| Chlorambucil daily+/-rituximab | Carboplatin/gemcitabine AUC 4-6/1g d1,d8 | 5-FU/LV + bevacizumab |
| Cisplatin 75/gemcitabine d1,8 | Carboplatin/pemetrexed | AC |
| Cisplatin/pemetrexed | Carboplatin/paclitaxel q3w | CAF |
| Dacarbazine | Cisplatin 100/gemcitabine d1,8 | Carboplatin/docetaxel q3w |
| Docetaxel weekly | ECF | CHOP |
| FOLFIRI | Fludarabine | Cisplatin/docetaxel 75/75 |
| Gemcitabine 1g 3/4 weeks | FOLFOX 85mg/m2 | Cisplatin/etoposide |
| Gemcitabine 1.25g 3/4 weeks | Gemcitabine 7/8 weeks then 3/4 | Cisplatin/gemcitabine d1,8,15 |
| Paclitaxel weekly or 3/4 weeks | Gemcitabine/irinotecan | Cisplatin/irinotecan |
| Pemetrexed | PEG doxorubicin 50 q4w | Cisplatin/paclitaxel 135-24h q3w |
| Temozolomide | XELOX | CMF classic |
| | | Doxorubicin q3w |
| | | FOLFOX 100-130 mg/m2 |
| | | Gemcitabine/docetaxel |
| | | Gemcitabine/nab-paclitaxel |
| | | Gemcitabine/pemetrexed d8 |
| | | Irinotecan q3w |
| | | Paclitaxel q3w |
| | | Docetaxel q3w |
| | | Topotecan monthly |
|
Unless specified otherwise, the doses are per meter squared. If no dose is specified, this means that the various common dosages used for this regimen all fall in the same category (e.g. docetaxel 60, 75, or 100 mg/m2 q3w)
Q3w, q4w: every 3 (4) weeks
|
Regimens not listed should be scored by analogy./
The boundaries between points are: MAX2 < 0.088 = 0; 0.089-0.149 = 1; >0.15 = 2
For more precise numbers (e.g. research purpose), please contact Dr Extermann
|